Dose ranges reflect commonly studied amounts in published research models. This is not medical advice. For research use only. Not for human consumption.
Protocol Comparison
Mitochondrial
Research dose range
Standard research range
2.5 - 5 mg
Training range — the dose most closely paired with exercise timing, where most research-planning protocols actually live.
Research focus
Metabolic signaling / insulin sensitivity
Observed window
4-8weeks
Administration
2-5x weekly
Primary pathway
AMPK / GLUT4 / Insulin sensitivity
Mechanism reference: Kim et al., Physiological Reports, 2019. Safety data: Phase 1 trial NCT03998514. Dosing reflects community research-planning protocols. For research use only.
PROTOCOL BENEFITS
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Activates AMPK and boosts GLUT4 expression in skeletal muscle — the same pathway your body switches on during exercise.
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Enhances insulin sensitivity, with a documented ~30% improvement in glucose disposal in controlled studies.
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Levels decline with age — centenarians show plasma MOTS-c levels resembling people decades younger, tying this peptide directly to metabolic resilience in exceptional aging.
SCIENCE
MOTS-c is unlike anything else in this catalog — a 16-amino acid peptide encoded directly in mitochondrial DNA, not nuclear DNA. It functions as a genuine mitochondrial signal, traveling to muscle, liver, and brain to coordinate metabolic response the way a hormone would.
A first-in-human Phase 1 study has already confirmed the safety picture — single subcutaneous doses up to 9.6mg, no serious adverse events reported. The insulin-sensitivity and metabolic effects that make MOTS-c compelling were established in animal models; human confirmation of those specific outcomes is the next chapter the research community is actively writing.
WHAT TO EXPECT
AMPK activation happens fast at the cellular level. Community-reported effects on energy and training capacity are often noted within the first 1-2 weeks of a cycle.
PROTOCOL NOTE
Available in 10mg. For research use only. Full documentation included with every order.
FAQ
It's the only compound in this category actually encoded in your mitochondrial DNA — not a synthetic analog mimicking a pathway, but a signal your own cells were built to produce.
It activates AMPK, the same pathway physical training triggers naturally — dosing 30-60 minutes before activity is the most common timing in research protocols.
